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Respiratory Resource Center

COPD & Lung Cancer: What's the Connection and How Can You Reduce Your Risk?

Aug 21, 2020 11:23:12 AM / by Devon Slavens

COPD & Lung Cancer_ Whats the Connection and How Can You Reduce Your Risk?

COPD is a complicated disease that comes with a variety of extraneous health concerns, including an increased risk for several other serious diseases. One of those diseases is lung cancer, a condition that is quite different from COPD, but still linked to the chronic lung disease in numerous ways.


Research shows people who have COPD are about twice as likely to develop lung cancer than people who don't have COPD. Unfortunately, research suggests that the vast majority of people with COPD have no idea about this increased lung cancer risk.

 

This lack of awareness is dangerous, because unaware COPD patients may be less likely to take important cancer-prevention measures or watch for lung cancer symptoms. This can result in fewer lung cancer screenings, later lung cancer diagnoses, and fewer efforts among COPD patients to make healthy lifestyle changes that could lower their lung cancer risk.

 

In this post, we're going to take a closer look at why there's such a strong connection between these two deadly lung diseases, including what factors tie them together and what sets them apart. We'll also discuss what this elevated risk for lung cancer means for people with COPD, explaining what types of lung cancers you might be at risk for and what you can do, specifically, to reduce your future lung cancer risk.

 

Lung Cancer and COPD: Fundamentally Different Yet Fundamentally Linked

Metal chain link

 

 

At first, it might seem strange that lung cancer and COPD are linked at all, especially when they are such vastly different types of diseases. After all, COPD is a chronic, lifelong illnesses and cancer is, well... cancer! And we often tend to think about cancer as a unique type of disease in a category all on its own.

 

But, while it's true that lung cancer and COPD are fundamentally different diseases, they actually have many characteristics in common—aside from the fact that they both affect the lungs. For example, both diseases can cause very similar breathing symptoms and they even share many of the same risk factors and causes.

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But to understand why having COPD increases your risk for lung cancer, you'll first need some basic knowledge about both of these diseases and how they work. Then, we can take a closer look at some key similarities and differences between lung cancer and COPD that can shed some light on how they're connected.

 

In the next few sections, we'll explain everything you need to know about lung cancer and COPD to get the most out of this guide, including what causes both diseases, how they develop, and how their progression compares.

 

Then, we'll jump right into discussing how the diseases are linked before giving you some helpful, science-based tips for how to reduce your risk for lung cancer if you have COPD.

 

The Basics of Lung Cancer vs COPD

 

Lungs

 

 

Lung cancer is a deadly disease caused by cancerous cells and tumors growing inside the lungs. It is the leading cause of cancer deaths in the US, killing more people than breast cancer, prostate cancer, and colorectal cancer combined; however, lung cancer can be cured with proper treatment in some cases, especially if you catch it early on.

 

By contrast, COPD is a chronic, lifelong disease that can be treated, but not cured. It is largely caused by damage and inflammation in the lung tissues and airways that makes it more and more difficult to breathe as the disease progresses.

 

Lung cancer begins as soon as cancerous cells appear in the lungs, though it can take some time before the cancer is detectable or the first symptoms start to appear. COPD, on the other hand, often doesn't have a clear beginning, as it is the result of chronic lung inflammation that occurs over the course of many years.

 

Most of the time, COPD is caused by smoking and long-term exposure to respiratory irritants like secondhand smoke and air pollution. Smoking is also the number one cause of lung cancer, though other respiratory irritants and carcinogenic substances (e.g. asbestos and radon gas) can also cause lung cancer, especially if you are exposed to them repeatedly over time.

 

How Cancerous Mutations Take Over Your Lungs

DNA strands

 

Image from Bstlee~commonswiki

 

Cancerous lung cells start as normal lung cells that become cancerous after acquiring certain types of DNA mutations. However, not all cell mutations are cancerous; some mutations are harmless, while others get corrected (or the whole cell gets destroyed) before they cause any problems.

 

So what is it exactly that makes a cancer cell different—and more dangerous—than a cell with a non-cancerous mutation or a healthy, normal cell? The answer is that cells only become cancerous when they develop several specific types of mutations that cause the cell to stop following certain “rules.”

 

In particular, cancer cells have mutations that allow them to multiply freely and ignore the usual controls that constrain how and when cells divide. They also have mutations that allow them to escape the body's natural defenses that would otherwise repair or destroy these mutated cells.

 

These cancerous cells are dangerous because the body can't detect and destroy them on its own; this allows the cancer cells to multiply out of control and spread to places they're never supposed to be. Eventually, these rogue cells begin to interfere with normal biological functions, though their exact effects depend on where the cancer is located and what types of mutations the cancer cells have.

 

Carcinogens and Lung Cancer

Pack of cigarettes

 

One thing that's important to know about cell mutations is that they can happen essentially by chance. They can happen any time a cell multiplies, or any time a cell's DNA gets copied, duplicated, or repaired.

 

However, some things—known as carcinogens—can cause a significant increase in DNA mutations. More mutations means a higher risk for cancer, since it creates more opportunities for a cancerous mutation to occur.

 

Some carcinogens, like UV radiation from sunlight, can mutate DNA directly by striking the DNA molecules or triggering a chemical reaction that damages DNA inside a cell. Other carcinogens, like tobacco smoke, indirectly mutate DNA by causing repeated inflammation and injury that damages DNA both in the cells it touches and in the surrounding tissues that get inflamed.

 

In general, your risk for cancer gets higher the more frequently you're exposed to cancer hazards. It's kind of like rolling a dice; your chances of developing a cancerous mutation on any given roll is very low, but the more times you roll the dice, the more likely you are to “roll” a cancerous mutation eventually.

 

Different Diseases, Similar Symptoms

Lungs

 

As we explained in the section above, lung cancer happens via a completely different biological mechanism than COPD. However, both diseases directly affect the lungs' ability to function, which means both diseases can cause some of the same respiratory symptoms.

 

COPD causes breathing symptoms because the damage it does to your lungs and airways restricts airflow to the lungs and reduces how much oxygen they can absorb. Lung cancer causes cancer cells to spread across healthy lung tissue and/or form tumors on the lungs, which interferes with normal functions and makes it more difficult to breathe.

 

Symptoms of COPD:

  • Shortness of breath
  • Difficulty breathing
  • Chronic cough (especially a wet cough that produces phlegm)
  • Wheezing
  • Chest tightness
  • Fatigue
  • Frequent respiratory infections
  • Swelling in legs, ankles, or feet
  • Unexplained weight loss (in the advanced stages of COPD)

Symptoms of Lung Cancer:

  • Shortness of breath
  • Difficulty breathing
  • Persistent cough (dry or wet)
  • Coughing up blood (or blood-streaked mucus)
  • Chest pain
  • Wheezing
  • Hoarse voice
  • Recurring lung infections
  • Chronic weakness or fatigue
  • Loss of appetite
  • Unexplained weight loss

 

Now, while some of these symptoms seem very similar, they can present themselves very differently in people with lung cancer versus people with COPD. Also, it's important to remember that every case of lung cancer and COPD is different, and symptoms can vary widely between people with the same disease.

 

One major difference between lung cancer and COPD symptoms is that COPD symptoms are life-long and don't get much better with treatment or time. They often start out very mild in the early stages of COPD and slowly get worse over the course of months and years.

 

Lung cancer symptoms, on the other hand, can get better with successful treatment and even fully disappear if the cancer is cured. However, symptoms often don't show up until the later stages of cancer, when the cancer is much less treatable and has likely already spread.

 

People who are diagnosed with early-stage COPD can live with the disease for many years before the symptoms get severe enough to significantly burden their lives. People with moderate to severe lung cancer symptoms are not likely to live long with the disease unless their cancer can be successfully treated or cured.

 

Certain Types of Lung Cancer are More Strongly Associated with COPD

Lung x-ray

 

There are at least a dozen different kinds of lung cancer, but the most common ones fall into one of two main types: small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC). Non-small cell lung cancers are by far the most common, and they make up about 80-85 percent of all lung cancers.

 

Compared to non-small cell lung cancers, small-cell lung cancers tend to be more aggressive and progress more quickly. However, every case of lung cancer is different, and how the disease presents and progresses can vary significantly from person to person.

 

All types of lung cancer are strongly associated with both smoking and COPD. About 85 percent of all lung cancers are caused by smoking, and about 40-70 percent of people with lung cancer also have COPD.

 

However, some types of lung cancer are more closely tied to smoking and COPD than others. People with COPD seem to be more prone to non-small cell lung cancers and have a particularly high risk for squamous cell carcinoma (a sub-type of NSCLC).

 

In fact, about half of all people who get non-small cell lung cancer also have COPD, and about 80 percent are current or former smokers. Small-cell lung cancers, by comparison, are almost always associated with smoking; up to 98 percent of of SCLC patients have a history of smoking.

 

Here is a table describing some of the most common types of lung cancers.

 

Type of Lung Cancer

Rarity

Cancer Sub-Types

Characteristics

Small Cell Lung Cancer (SCLC)

Rare: only about 10-15% of lung cancers are small cell lung cancers.

Small cell carcinoma and combined small cell carcinoma

Small cell lung cancers tend to be fast-growing and aggressive.

Non-Small Cell Lung Cancer (NSCLC)

Common: about 80-85% of lung cancers are non-small cell lung cancers.

Adenocarcinoma of the lung (~30% of NSCLC's), squamous cell lung cancer (~30% of NSCLC's), large-cell undifferentiated carcinoma (~10-15% of NSCLC's)

Non-small cell lung cancers are slower-growing and usually have few symptoms (or none at all) until the later stages. However, large-cell undifferentiated carcinoma tends to progress more quickly than other NSCLC types.

Lung Nodules

Common, though only a small percentage become cancerous

 

Usually slow-growing if cancerous, though most lung nodules are benign (non-cancerous) and simply need to be monitored for growth or change. To learn more about lung nodules, check out our guide on the topic.

Other Lung Cancers

Very rare

Adenosquamous carcinoma of the lung (a small-cell lung cancer), large cell neuroendocrine carcinoma (a non-small cell lung cancer), salivary gland-type lung carcinoma, lung carcinoids, mesothelioma, sarcomatoid carcinoma of the lung (extremely rare), malignant granular cell lung tumor (extremely rare)

Varies depending on type

 

It's important to note that lung cancer doesn't always stay just in the lungs. Over time, lung cancer can become metastatic, which means that the cancer cells can break off and travel to other parts of the body.

 

This allows the cancer to take root in other organs, most commonly the bones, brain, liver, adrenal gland, and the other lung. When this happens, the resulting cancer is known as a secondary cancer, and it retains the same characteristics as the cancer it originally came from.

 

Why Do People With COPD Have a Higher Risk for Lung Cancer?

 

Now that you know the basics of how both lung cancer and COPD work, let's take a closer look at why one disease affects the other and how both of these diseases are so closely intertwined. We'll look at 3 main factors in particular that help explain the link: shared disease risk factors, accumulated lung damage, and individual susceptibility to lung disease.

 

Shared Risk Factors

Man smoking a cigarette

 

One of the main links between COPD and lung cancer is that both diseases have many of the same risk factors and causes. A risk factor is essentially any kind of health problem, physical characteristic, behavior, or lifestyle factor that is known to increase your risk for developing a certain disease.

 

This means that some of the things that increase your chances of developing COPD—like tobacco smoke and certain respiratory toxins—can also increase your risk of developing lung cancer. In fact, up to 90% of both COPD cases and lung cancer cases are caused by smoking.

 

This makes sense if you consider the fact that COPD, just like lung cancer, is associated with repeated damage and inflammation in the lungs. Even if you're not a smoker, being diagnosed with COPD means that you are more likely than people who don't have COPD to have other risk factors that increase your chances of getting lung cancer in the future.

 

Danger sign

 

Let's take a closer look at the risk factors for both lung cancer and COPD. Though some of the risk factors differ, you should notice that there are a lot that overlap.

 

Risk Factors for Lung Cancer:

  • Older age
  • Smoking tobacco (responsible for about 80% of lung cancer deaths)
  • Exposure to secondhand smoke (responsible for up to 7 thousand deaths per year)
  • Exposure to radon gas (the second most common cause of lung cancer)
  • Exposure to asbestos (especially in an occupational environment)
  • Exposure to other carcinogens at work (e.g. diesel exhaust fumes, coal compounds, silica dust, arsenic, etc.)
  • Exposure to air pollution
  • Previous radiation therapy
  • Family history of lung cancer

 

Risk Factors for COPD:

  • Older age
  • Smoking tobacco (the number one cause of COPD)
  • Exposure to secondhand smoke
  • Exposure to radon gas
  • Exposure to asbestos
  • Exposure to other respiratory irritants, including hazardous fumes, chemicals, and airborne particles, especially in an occupational environment (e.g. dust, car exhaust, and fumes from products like cleaning solutions, adhesives, treated lumber, etc.)
  • Exposure to air pollution
  • A history of frequent or severe respiratory infections (especially during childhood)
  • Alpha-1 Antitrypsin Deficiency (a rare genetic disease)

 

Lung Damage Caused by COPD

Lungs

 

While common risk factors (like genetics) and common causes (like smoking) explain some of the relationship between lung cancer and COPD, there are other factors at play. Research shows that simply having COPD is an independent risk factor for lung cancer on its own.

 

Researchers also believe that certain types of lung cancer—squamous cell carcinoma, in particular—are the result of COPD-related inflammation in the lungs. After all, chronic inflammation is a well-known cause of cancer as well as an inherent characteristic of COPD

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This chronic inflammation causes certain physiological changes to lung tissues, including a decrease in DNA repair proteins and an increase in oxidative stress. These changes—along with the repeated cycles of inflammation, damage, and repair—can lead to cancerous mutations.

 

Ultimately, this evidence suggests that COPD—and the inflammation associated with it—is not just linked to lung cancer, but might also be a direct cause of lung cancer in some people. Unfortunately, if you have COPD, there's not much you can do about this particular lung cancer risk.

 

However, some early research suggests that treatment with COPD medications—inhaled steroids, specifically—might reduce the lung cancer risk for some people with COPD. However, further research is needed to confirm these findings, and, (as of yet) there is no clear way to reduce your risk of getting cancer as a result of having COPD.

 

Individual Susceptibility

 

Person in a crowd

 

Some people seem to be more susceptible to lung cancer and COPD than others, which is one of the reasons why only a small percentage of people who smoke end up getting lung diseases. This variability comes from a variety of different factors, including genetics and other physical characteristics like immune system activity (though there's also a heavy dose of chance involved).

 

The result is that some people are more prone to developing lung cancer than others; likewise, some people seem to be more likely than others to get COPD. Experts believe these people may have specific genetic or biological traits that make their lungs more vulnerable to disease.

 

Researchers haven't yet pinpointed exactly which traits these are, but they have some educated guesses. Some studies have even identified specific genes that are linked to both a higher risk for lung cancer and a higher risk for COPD.

 

DNA strands

 

Other biological traits could include hyper-sensitive lungs that are prone to inflammation. This could be the result of differences in how their immune system (and their inflammatory response) works, or how their lungs react to respiratory irritants.

 

Even something as simple as having smaller-sized airways could make you more vulnerable to lung diseases. This could be because small airways affect lung function, or because less total airway tissue can result in a larger dose of exposure to the irritants and carcinogens you breathe; some researchers even think this may be one of the reasons why women who smoke are more likely to get COPD than men who smoke.

 

This phenomenon is similar to shared risk factors in the sense that, in this case, it's not the COPD itself that puts you at risk for cancer, but rather a separate, common factor—in this case, certain genetic and physiological traits. In other words, if you happen to have a biology that makes your lungs more susceptible to cancer, that same biology might also make you more susceptible to COPD.

 

How to Reduce Your Lung Cancer Risk

 

Cancer

 

Even though COPD makes you more vulnerable to lung cancer, it doesn't mean that your risk for cancer is completely out of your control. How you live your life and how well you adhere to a healthy lifestyle can have a significant influence on your risk for cancer, and certain habits may even have cancer-preventing effects.

 

Quit Smoking!

No smoking

 

 

Nowadays, most people know that smoking causes lung cancer and other deadly diseases (like COPD). However, one thing that many smokers don't realize is that quitting smoking can significantly reduce their future lung cancer risk.

 

This is true regardless of your age or how long you've been smoking, which is why experts say “it's never too late to quit.” While your risk for lung cancer will never be zero, the risk decreases more the longer you manage to stay smoke-free.

 

According to the American Cancer Society, ten years after you quit smoking your risk for lung cancer will have decreased by half of what it was when you used to smoke. And that's just one of the many, many benefits of quitting, which include fewer respiratory symptoms and a lower risk for lung infections, heart attacks, heart disease, and stroke.

 

If you are a current smoker, quitting is the number one thing you can do to reduce your chances of getting lung cancer, and it's also one of the best things you can do for COPD. If you're interested in learning more about how to quit smoking and the many resources available to help people quit, check out our Quit-Smoking Guide from our Respiratory Resource Center.

 

Get a Radon Test

Radon warning sign

 

 

Radon gas is the second most common cause of lung cancer, and the number one cause of lung cancer in non-smokers. It's an invisible, radioactive gas that can seep up from the ground and build up your house, exposing you to dangerous levels of radon in your own home.

 

The main way radon gets indoors is through pipes and home foundations, but luckily there is a fix. You can get a cheap radon test kit to test your home's radon levels, and if they're too high you can install a radon mitigation system.

 

Any home can have radon, and it's impossible to detect unless you get a proper test. Fortunately, radon tests are cheap and easy to do; unfortunately, many people don't get their homes tested, and live unaware for years or even decades in radon-filled homes.

 

While it can be tempting to the potential problem, radon gas is no joke. Detecting and treating radon build-up is one of the most important things you can do to prevent lung cancer, and the sooner you get your home tested, the sooner you can rest assured that you're not breathing a deadly carcinogen in your own home.

 

Avoid Beta-carotene Supplements (If You Smoke)

Beta carotene supplements
Image from Ragesoss

 

Some research shows that smokers who take beta-carotene supplements get lung cancer at a higher rate than smokers who don't. Because of this, experts advise people who smoke tobacco to avoid beta-carotene supplements altogether—unless prescribed by your doctor, of course.

 

However, foods that contain beta-carotene and other similar carotenoids (e.g. dark, leafy greens and many yellow and orange vegetables) are considered safe to eat and should not increase your risk for lung cancer, even if you smoke. In fact, research suggests that these vegetables may even reduce your risk for lung cancer and other types of cancer, including cancers of the mouth, esophagus, larynx, and pharynx.

 

If you are a current smoker and take a supplement (such as a multivitamin) that contains beta-carotene, consider stopping or replacing the supplement with one that is that beta-carotene free. Of course, you should always discuss any major changes you plan to make to your diet or supplement intake with your doctor first.

 

Stay Away From Respiratory Irritants

Air pollution

 

Every time you breathe in irritants, toxins, and carcinogens from the air, it risks causing irritation and inflammation in your lungs—even more so if you have COPD. Over time and repeated exposure, this increases your risk both for long-term lung damage and for developing cancerous mutations in your lungs.

 

That's why you should make it your goal to avoid these respiratory hazards as much as possible throughout your life. That means avoiding unhealthy habits (like smoking) that expose you to carcinogens and making an extra effort to stay away from lung irritants like air pollution and second-hand smoke.

 

Unfortunately, respiratory hazards can be tricky to avoid, and most of us encounter many of them over the course of a normal day. That's why it's important to learn some practical strategies and techniques to help you reduce your exposure and incorporate those habits into your everyday life.

 

If you'd like to learn more about these techniques and other ways to avoid respiratory irritants, you can find all kinds of information on this topic online and in our Respiratory Resource Center. To help you get started, here are a few links to relevant guides with all kinds of practical advice for protecting your lungs at home, outdoors, and in a variety of hazardous situations.

 

 

Get Regular Lung Cancer Screenings

Lung screening procedure

 

While lung cancer screenings won't exactly prevent cancer, they can significantly increase your chances of surviving lung cancer by catching it early on. Screenings are the best way to diagnose lung cancer while it's sill in the early stages, before it advances to a more serious—and less treatable—later stage.

 

Lung cancer screenings are quick and painless, and involve a special type of X-ray imaging called a CT scan. The scan produces a detailed picture of your lungs that a specialist will analyze for signs of cancer.

 

CT scans are not foolproof, however; they can't catch all types of lung cancer, and it cannot guarantee you will survive a cancer the screening identifies. However, research shows that lung cancer screenings do decrease lung cancer deaths due to their high success rates for early cancer detection.

 

If you have any major risk factors for lung cancer, including a history of smoking, you should talk to your doctor about if—and when—you should start getting screened. Experts recommend that people who have the following three risk factors get a lung cancer screening every year:

 

  • Age between 55 and 80 years old
  • A history of heavy smoking
  • Current smoking or smoking within the past 15 years

 

If your doctor says you would benefit from getting screened for lung cancer, don't put it off for or avoid it for fear of bad news. Getting regular screenings can mean the difference between getting diagnosed with early-stage lung cancer and surviving, and getting diagnosed with late-stage cancer that cannot be cured.

 

Don't Discount the Importance of a Healthy Diet and Exercise

Healthy lifestyle
Image from Courtesy Graphic

 

Having a nutritious diet and getting physical activity are vital components of a healthy lifestyle in general, but they are also key factors in your lifetime cancer risk. Eating right and exercising can reduce your risk for many cancers, including lung cancer, while failing to do so can increase your cancer risk.

 

And while anyone can benefit from the cancer-preventing effects of a healthy lifestyle, it's particularly important for people who have serious lung cancer risk factors (including a history of smoking or COPD). You can't make up for the damage that's already been done, but you can make better health decisions now that could reduce your future cancer risk.

 

The American Cancer Society estimates that poor lifestyle choices related to diet, exercise, and alcohol intake are responsible for up to 18% of cancers and 16% of cancer deaths—all cancers that could have been prevented. Fortunately, your lifestyle is something that you have the power to change and control, and it's never too late to improve!

 

Of course, it's not easy to make major lifestyle changes, and it can take time to build up the skills and habits to make it work long-term. However, the earlier you start, the better, and every small step you take to build a healthier lifestyle is always better than doing nothing at all.

 

Man walking in a field

 

Even if you struggle to exercise because of your COPD symptoms, you can start with light activities like stretching and walking a little bit each day. There are plenty of things you can do to stay active, even with limited mobility, breathlessness, or any other physical limitations you may have.

 

If you have trouble starting or sticking to a diet and exercise routine, talk to your doctor about seeing a specialist like a registered dietitian or physical therapist, see if you meet the criteria for a pulmonary rehabilitation class. Working with a professional is a great way to get personalized training and help setting up a meal or work-out plan that's both realistic and appropriate for your needs.

 

If you'd like some more tips on how to eat healthy and stay active with COPD, check out the following guides from our Respiratory Resource Center:

 

 

Remember: Long-term Habits are Key

Calendar

 

Lots of different things factor in to your lifetime risk for cancer, including diet, exercise, and exposure to a wide range of carcinogenic (cancer-promoting) substances. It's important to understand that these various factors add up over a lifetime; it's your cumulative exposure to risk factors that influences your overall cancer risk.

 

This means that the longer you live an unhealthy lifestyle, the more carcinogens you'll be exposed to, and the higher your risk for cancer will be. That's why improving your lifestyle now is better than putting it off till later—especially if your lungs are already damaged from smoking or COPD.

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The same goes for long-term exposure to lung irritants like dust, exhaust fumes, and first-hand or second-hand smoke. Cumulative exposure matters; the more frequently you expose your lungs to these known carcinogens, the more you increase your lung cancer risk.

 

That's why the American Cancer Association (ACA) emphasizes life-long, healthy habits as a first-line defense against against cancer. There are several healthy habits that the ACA recommends in particular that are well-supported by research as effective techniques to reduce your overall cancer risk:

 

Conclusion

If you or a loved one has COPD, it's important to know how the disease affects your long-term health, including your risk for other lung conditions like lung cancer. Unfortunately, there's no getting around the fact that COPD increases your chances of getting lung cancer, but that doesn't mean that there's nothing you can do to modify your lung cancer risk.

 

We've discussed several different things you can do to lower your risk for cancer in general as well as lung cancer specifically, including living a healthy lifestyle, reducing your exposure to cancer-causing substances, and (most importantly) quitting smoking. You can also get lung cancer screenings to increase your chances of catching the cancer early while it can still be cured.

 

This is why every person with COPD needs to know about the link between COPD and lung cancer and the very real danger it can pose. The more you know, the more you can do to protect yourself and manage your lifestyle to minimize your future lung cancer risk.

Topics: COPD, Medication and Treatment, wellness goals, COPD education, COPD management, wellness for seniors

Devon Slavens

Written by Devon Slavens

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